1 post tagged “causes of lactose intolerance.”

Lactose intolerance is the inability to digest significant amounts of lactose, the major sugar found in milk. Lactose intolerance is caused by a shortage of the enzyme lactase, which is produced by the cells that line the small intestine. Lactase breaks down milk sugar into two simpler forms of sugar called glucose and galactose, which are then absorbed into the bloodstream. Not all people deficient in lactase have the symptoms commonly associated with lactose intolerance, but those who do are said to have lactose intolerance.

The normal mammalian condition is for the young of a species to experience reduced lactase production at the end of the weaning period (a species-specific length of time). In non dairy consuming societies, lactase production usually drops about 90% during the first four years of life, although the exact drop over time varies widely. However, certain human populations have a mutation on chromosome 2 which results in a bypass of the common shutdown in lactase production, making it possible for members of these populations to continue consumption of fresh milk and other dairy products throughout their lives.

The cells that line your small intestine produce an enzyme called lactase. Lactase breaks down lactose into two simple sugars — glucose and galactose — which can be absorbed into your bloodstream. Without lactase, the unprocessed lactose moves on to the colon, where the normal intestinal bacteria contend with it. This causes the hallmarks of lactose intolerance — gas, bloating and diarrhea.

Lactose, a disaccharide, is present in milk and processed foods. Dietary lactose must be hydrolyzed to a monosaccharide in order to be absorbed by the small intestinal mucosa. A deficiency of intestinal lactase prevents hydrolysis of ingested lactose. The osmotic load of the unabsorbed lactose causes secretion of fluid and electrolytes until osmotic equilibrium is reached. Dilation of the intestine caused by the osmosis induces an acceleration of small intestinal transit, which increases the degree of maldigestion. Within the large intestine, free lactose is fermented by colonic bacteria to yield short-chain fatty acids and hydrogen gas. 

When lactose moves through the large intestine (colon) without being properly digested, it can cause uncomfortable symptoms such as gas, belly pain, and bloating. Some people with lactose intolerance cannot digest any milk products, while others can eat or drink small amounts of milk products or certain types of milk products without problems.

Lactose intolerance is fairly common. It seems to affect guys and girls equally. Some ethnic groups are more likely to be affected than others because their diets traditionally include fewer dairy products: Almost all Asians and Native Americans are lactose intolerant, and up to 80% of African Americans and Hispanic Americans also have symptoms of lactose intolerance. Their ancestors did not eat dairy foods, so their bodies were not prepared to digest dairy, and they passed these genes on from generation to generation.

Many people who have gas, belly pain, bloating, and diarrhea suspect they may be lactose-intolerant. The best way to check this is to avoid eating all milk and dairy products to see if your symptoms go away. If they do, then you can try adding small amounts of milk products to see if your symptoms come back.

The common symptoms of lactose intolerance are gastrointestinal, primarily, abdominal pain, diarrhea, flatulence (passing gas), and, less commonly, abdominal bloating, abdominal distention, and nausea. Unfortunately, these symptoms can be caused by other gastrointestinal conditions or diseases, so the presence of these symptoms is not very good at predicting whether a person has lactase deficiency or lactose intolerance.